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Article

The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.

Frontiers in immunology - 1 Jan 2023

Rahmouni Myriam, De Marco Lorenzo, Spadoni Jean-Louis, Tison Maxime, Medina-Santos Raissa, Labib Taoufik, Noirel Josselin, Tamouza Ryad, Limou Sophie, Delaneau Olivier, Fellay Jacques, Bensussan Armand, Le Clerc Sigrid, McLaren Paul J, Zagury Jean-François

Abstract excerpt

Introduction: We have reanalyzed the genomic data of the International Collaboration for the Genomics of HIV (ICGH), centering on HIV-1 Elite Controllers. Methods: We performed a genome-wide Association Study comparing 543 HIV Elite Controllers with 3,272 uninfected controls of European descent. Using the latest database for imputation, we analyzed 35,552 Single Nucleotide Polymorphisms (SNPs) within the Major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38146367
DOI: 10.3389/fimmu.2023.1305856
PMCID: PMC10749428

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