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Article

Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 May 2010

He Xiao Ping, Pan Enhui, Sciarretta Carla, Minichiello Liliana, McNamara James O

Abstract excerpt

The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cgamma1 (PLCgamma1) signaling is the key pathway and tested this in trkB(PLC/PLC) mice carrying a mutation (Y816F) that uncouples TrkB from PLCgamma1. Biochemical measures revealed activation of both TrkB and PLCgamma1 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20445044
DOI: 10.1523/JNEUROSCI.5821-09.2010
PMCID: PMC2872928

Genes

BDNF
CA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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