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Article

A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice.

Neuropharmacology - 1 Jun 2010

Hadjab-Lallemend Saïda, Wallis Karin, van Hogerlinden Max, Dudazy Susi, Nordström Kristina, Vennström Björn, Fisahn André

Abstract excerpt

Thyroid hormone deficiency during early developmental stages causes a multitude of functional and morphological deficits in the brain. In the present study we investigate the effects of a mutated thyroid hormone receptor TR alpha 1 and the resulting receptor-mediated hypothyroidism on the development of GABAergic neurotransmission and seizure susceptibility of neuronal networks. We show that mutant mice have a...

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Identifiers

PMID: 20153760
DOI: 10.1016/j.neuropharm.2010.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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