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Article

Disruption of PLC-beta 1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration.

Molecular and cellular neurosciences - 1 Dec 2002

Böhm Detlef, Schwegler Herbert, Kotthaus Lisa, Nayernia Karim, Rickmann Michael, Köhler Michael, Rosenbusch Joachim, Engel Wolfgang, Flügge Gabriele, Burfeind Peter

Abstract excerpt

Aberrant reorganization of hippocampal mossy fibers occurs in human temporal lobe epilepsy and rodent epilepsy models. We generated a mouse model showing massive late-onset aberrant mossy fiber sprouting in the adult hippocampus. The mutation in this mouse model derives from an intronic insertion of transgene DNA in the mouse PLC-beta1 gene (PLC-beta 1(-/-)(TC) mutation) leading to a splice mutation of the...

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Identifiers

PMID: 12504592
DOI: 10.1006/mcne.2002.1199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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