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Article

Latrophilin GPCR signaling mediates synapse formation.

eLife - 1 Mar 2021

Sando Richard, Südhof Thomas C

Abstract excerpt

Neural circuit assembly in the brain requires precise establishment of synaptic connections, but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are postsynaptic adhesion-GPCRs that engage in trans-synaptic complexes with presynaptic teneurins and FLRTs. In mouse CA1-region neurons, Latrophilin-2 and Latrophilin-3 are essential for formation of entorhinal-cortex-derived and...

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Identifiers

PMID: 33646123
DOI: 10.7554/eLife.65717
PMCID: PMC7954527

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