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Article

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.

Cell death & disease - 1 Jun 2020

Fernández-García Sara, Sancho-Balsells Anna, Longueville Sophie, Hervé Denis, Gruart Agnès, Delgado-García José María, Alberch Jordi, Giralt Albert

Abstract excerpt

Astrocytes have emerged as crucial regulators of neuronal network activity, synapse formation, and underlying behavioral and cognitive processes. Despite some pathways have been identified, the communication between astrocytes and neurons remains to be completely elucidated. Unraveling this communication is crucial to design potential treatments for neurological disorders like temporal lobe epilepsy (TLE). The...

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Identifiers

PMID: 32483154
DOI: 10.1038/s41419-020-2615-9
PMCID: PMC7264221

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