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Article

Mechanism of TrkB-mediated hippocampal long-term potentiation.

Neuron - 26 Sept 2002

Minichiello Liliana, Calella Anna Maria, Medina Diego L, Bonhoeffer Tobias, Klein Rüdiger, Korte Martin

Abstract excerpt

The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However, the downstream pathways required to mediate these functions are unknown. We have studied mice with a targeted mutation in either the Shc or the phospholipase Cgamma (PLCgamma) docking sites of TrkB (trkB(SHC/SHC) and trkB(PLC/PLC) mice). We found that hippocampal long-term potentiation...

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Source

Identifiers

PMID: 12367511
DOI: 10.1016/s0896-6273(02)00942-x

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mechanism of TrkB-mediated hippocampal long-term potentiation.PMID 12367511Read ↗

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