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Article

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.

Brain research - 20 Mar 2008

Pacheco Otalora Luis F, Hernandez Eder F, Arshadmansab Massoud F, Francisco Sebastian, Willis Michael, Ermolinsky Boris, Zarei Masoud, Knaus Hans-Guenther, Garrido-Sanabria Emilio R

Abstract excerpt

In the hippocampus, BK channels are preferentially localized in presynaptic glutamatergic terminals including mossy fibers where they are thought to play an important role regulating excessive glutamate release during hyperactive states. Large conductance calcium-activated potassium channels (BK, MaxiK, Slo) have recently been implicated in the pathogenesis of genetic epilepsy. However, the role of BK channels in...

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Source

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Identifiers

PMID: 18295190
DOI: 10.1016/j.brainres.2008.01.017
PMCID: PMC2346580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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