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Article

Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995

Butler L S, Silva A J, Abeliovich A, Watanabe Y, Tonegawa S, McNamara J O

Abstract excerpt

Multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMK) phosphorylates proteins pivotally involved in diverse neuronal processes and thereby coordinates cellular responses to external stimuli that regulate intracellular Ca2+ [Hanson, P. I. & Schulman, H. (1992) Annu. Rev. Biochem. 61, 559-664]. Despite extensive study, the impact of this enzyme on control of the excitability of neuron populations in...

Topics

Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Electric Stimulation
Electroencephalography
Epilepsy
Hippocampus
Isoenzymes
Limbic System
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mice, Transgenic

Mutation

Protein Kinase C

Seizures

Source

Open in PubMed Open full text

Identifiers

PMID: 7624331
DOI: 10.1073/pnas.92.15.6852
PMCID: PMC41427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7624331-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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