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Article

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.

Nucleic acids research - 16 Nov 2016

Jennings Martin D, Kershaw Christopher J, White Christopher, Hoyle Danielle, Richardson Jonathan P, Costello Joseph L, Donaldson Ian J, Zhou Yu, Pavitt Graham D

Abstract excerpt

In protein synthesis translation factor eIF2 binds initiator tRNA to ribosomes and facilitates start codon selection. eIF2 GDP/GTP status is regulated by eIF5 (GAP and GDI functions) and eIF2B (GEF and GDF activities), while eIF2α phosphorylation in response to diverse signals is a major point of translational control. Here we characterize a growth suppressor mutation in eIF2β that prevents eIF5 GDI and alters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27458202
DOI: 10.1093/nar/gkw657
PMCID: PMC5175340

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eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.PMID 27458202Read ↗

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.Semantic proximity Read ↗

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.Semantic proximity Read ↗

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.Semantic proximity Read ↗

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2Semantic proximity Read ↗

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.Semantic proximity Read ↗

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.Semantic proximity Read ↗

Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.Semantic proximity Read ↗

Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.Semantic proximity Read ↗

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.Semantic proximity Read ↗

A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.Semantic proximity Read ↗

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