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Article

MNK2 deficiency potentiates β-cell regeneration via translational regulation

13 Jun 2022

Abstract excerpt

Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of β-cell regeneration, but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that CID661578 targets MAP kinase-interacting serine/threonine kinase 2 (MNK2), an interaction we genetically validated...

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PMID: 35697798
DOI: 10.1038/s41589-022-01047-x

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