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Article

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

PloS one - 1 Jan 2008

Labalette Charlotte, Nouët Yann, Levillayer Florence, Armengol Carolina, Renard Claire-Angélique, Soubigou Guillaume, Xia Tian, Buendia Marie-Annick, Wei Yu

Abstract excerpt

BACKGROUND: Four and a half LIM-only protein 2 (FHL2) has been implicated in multiple signaling pathways that regulate cell growth and tissue homeostasis. We reported previously that FHL2 regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts (MEFs) display reduced levels of cyclin D1 and low proliferative activity. METHODOLOGY/PRINCIPAL FINDINGS: Here we address the contribution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19018287
DOI: 10.1371/journal.pone.0003761
PMCID: PMC2583050

Genes

FHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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