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Article

Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.

Molecular carcinogenesis - 1 Jul 2024

Zhang Shaoting, Zhang Liangying, Zhang Dan, Guo Yue, Gao Yisha, Jiang Zongying, Li Shujing, Liu Anbu, Cao Xu, Tian Jinhai, Zhao Sien, Yu Yuanyuan, Yang Wei, Bai Ru, Huang Ling, Yan Hongli, Zhao Hui, Sun Jianmin

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are predominately induced by KIT mutants. In this study, we found that four and a half LIM domains 2 (FHL2) was highly expressed in GISTs and KIT signaling dramatically increased FHL2 transcription while FHL2 inhibited KIT transcription. In addition, our results showed that FHL2 associated with KIT and increased the ubiquitination of both wild-type KIT and primary KIT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38629424
DOI: 10.1002/mc.23727

Genes

KIT
FHL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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