Article
Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness.
Allergy - 1 Dec 2015
Kurakula K, Vos M, Logiantara A, Roelofs J J T H, Nieuwenhuis M A, Koppelman G H, Postma D S, Brandsma C A, Sin D D, Bossé Y, Nickle D C, van Rijt L S, de Vries C J M
Abstract excerpt
BACKGROUND: Asthma is an inflammatory disease that involves airway hyper-responsiveness and mucus hypersecretion. The LIM-only protein FHL2 is a crucial modulator of multiple signal transduction pathways and functions as a scaffold in specific protein-protein interactions. OBJECTIVE: We sought to investigate the role of FHL2 in airway inflammation. METHODS: Allergic airway inflammation was induced in WT and...
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