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Article

Structural allele-specific patterns adopted by epitopes in the MHC-I cleft and reconstruction of MHC:peptide complexes to cross-reactivity assessment.

PloS one - 26 Apr 2010

Antunes Dinler A, Vieira Gustavo F, Rigo Maurício M, Cibulski Samuel P, Sinigaglia Marialva, Chies José A B

Abstract excerpt

The immune system is engaged in a constant antigenic surveillance through the Major Histocompatibility Complex (MHC) class I antigen presentation pathway. This is an efficient mechanism for detection of intracellular infections, especially viral ones. In this work we describe conformational patterns shared by epitopes presented by a given MHC allele and use these features to develop a docking approach that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20442757
DOI: 10.1371/journal.pone.0010353
PMCID: PMC2860844

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Source receipt: pubmed, retrieved 7 Sept 2026.

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