Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural in silico analysis of cross-genotype-reactivity among naturally occurring HCV NS3-1073-variants in the context of HLA-A*02:01 allele.

Molecular immunology - 1 Jul 2011

Antunes Dinler A, Rigo Maurício M, Silva Jader P, Cibulski Samuel P, Sinigaglia Marialva, Chies José A B, Vieira Gustavo F

Abstract excerpt

Cellular immune response plays a central role in outcome of Hepatitis C Virus (HCV) infection. While specific T-cell responses are related to viral clearance, impaired responses can lead to chronic infection, turning HCV variability into a major obstacle for vaccine development. In a recent work, Fytili et al. (2008) studied the cross reactive potential of HCV specific CD8+ T-cells and observed a large variation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Hepatitis C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to Immunity, Cellular

Share to Principal Component Analysis

Share to Receptors, Antigen, T-Cell

Share to Static Electricity

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 21513985
DOI: 10.1016/j.molimm.2011.03.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural in silico analysis of cross-genotype-reactivity among naturally occurring HCV NS3-1073-variants in the context of HLA-A*02:01 allele.PMID 21513985Read ↗

Structural allele-specific patterns adopted by epitopes in the MHC-I cleft and reconstruction of MHC:peptide complexes to cross-reactivity assessment.Semantic proximity Read ↗

Molecular Modeling and In Silico Design of a Novel T-Cell (MHC-II) Epitope-Based Vaccine Against HCV: Immunoinformatics Approaches for the South Asian PopulationSemantic proximity Read ↗

Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.Semantic proximity Read ↗

Biochemical and structural impact of natural polymorphism in the HLA-A3 superfamily.Semantic proximity Read ↗

Prediction of potential NS3-based T cell epitopes of hepatitis C virus by in-silico and in-vitro approach.Semantic proximity Read ↗

Vaccine Development T-cell (MHC-I) Epitopes Identification Against the Indian HCV Genotype: An Approach Based on Immunoinformatic.Semantic proximity Read ↗

A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV).Semantic proximity Read ↗

Epitope-based therapeutic targets in HCV genotype 1 non-structural proteins: a novel strategy to combat emerging drug resistance.Semantic proximity Read ↗

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.Semantic proximity Read ↗

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.Semantic proximity Read ↗

Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: towards designing better vaccines.Semantic proximity Read ↗

CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.