Article
Peptide binding prediction for the human class II MHC allele HLA-DP2: a molecular docking approach.
BMC structural biology - 14 Jul 2011
Patronov Atanas, Dimitrov Ivan, Flower Darren R, Doytchinova Irini
Abstract excerpt
BACKGROUND: MHC class II proteins bind oligopeptide fragments derived from proteolysis of pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells. Human MHC class II alleles are grouped into three loci: HLA-DP, HLA-DQ and HLA-DR. In contrast to HLA-DR and HLA-DQ, HLA-DP proteins have not been studied extensively, as they have been viewed as less important in immune responses than...
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