Article
Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release.
Blood - 1 Sept 2003
Schraw Todd D, Rutledge Tara W, Crawford Garland L, Bernstein Audrey M, Kalen Amanda L, Pessin Jeffery E, Whiteheart Sidney W
Abstract excerpt
It is widely accepted that the platelet release reaction is mediated by heterotrimeric complexes of integral membrane proteins known as SNAREs (SNAP receptors). In an effort to define the precise molecular machinery required for platelet exocytosis, we have analyzed platelets from cellubrevin/VAMP-3 knockout mice. Cellubrevin/VAMP-3 has been proposed to be a critical v-SNARE for human platelet exocytosis;...
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