Article
α-granule biogenesis: from disease to discovery.
Platelets - 1 Mar 2017
Chen Chang Hua, Lo Richard W, Urban Denisa, Pluthero Fred G, Kahr Walter H A
Abstract excerpt
Platelets are critical to hemostasis and thrombosis. Upon detecting injury, platelets show a range of responses including the release of protein cargo from α-granules. This cargo is synthesized by platelet precursor megakaryocytes or endocytosed by megakaryocytes and/or platelets. Insights into α-granule biogenesis have come from studies of hereditary conditions where these granules are immature, deficient or...
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