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Article

Rab27b regulates number and secretion of platelet dense granules

23 Mar 2007

Abstract excerpt

The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Rab27a has been shown previously to regulate organelle movement and regulated exocytosis in a wide variety of secretory cells. However, the role of the more restrictedly expressed Rab27b remains unclear. Here we describe the creation of Rab27b knockout (KO) strain that was subsequently crossed with the naturally occurring...

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PMID: 17384153
DOI: 10.1073/pnas.0609879104

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