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Article

The winding road to platelet α-granules

16 Apr 2025

Abstract excerpt

Platelets are anucleate cellular fragments derived from megakaryocytes (MKs) and α-granules constitute their most numerous membrane-bound compartments. These granules play a role in platelet aggregation to form a hemostatic plug but also contain numerous cargo proteins with key functions in angiogenesis, inflammation, wound healing and cancer. Human genetic disorders that cause deficiencies in the biogenesis of...

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PMID: 40309239
DOI: 10.3389/fcell.2025.1584059

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