Article
Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.
Traffic (Copenhagen, Denmark) - 1 Jul 2013
Dudenhöffer-Pfeifer Monika, Schirra Claudia, Pattu Varsha, Halimani Mahantappa, Maier-Peuschel Monika, Marshall Misty R, Matti Ulf, Becherer Ute, Dirks Jan, Jung Martin, Lipp Peter, Hoth Markus, Sester Martina, Krause Elmar, Rettig Jens
Abstract excerpt
In order to fuse lytic granules (LGs) with the plasma membrane at the immunological synapse, cytotoxic T lymphocytes (CTLs) have to render these LGs fusion-competent through the priming process. In secretory tissues such as brain and neuroendocrine glands, this process is mediated by members of the Munc13 protein family. In human CTLs, mutations in the Munc13-4 gene cause a severe loss in killing efficiency,...
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