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Article

Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes

13 Jan 2022

Abstract excerpt

Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets. We investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35021601
DOI: 10.3324/haematol.2021.279636

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