Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.

doi:10.1080/01635580903441279

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Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.

Nutrition and cancer - 1 Jan 2010

Iwasaki Motoki, Hamada Gerson Shigeaki, Nishimoto Ines Nobuko, Netto Mario Mourão, Motola Juvenal, Laginha Fábio Martins, Kasuga Yoshio, Yokoyama Shiro, Onuma Hiroshi, Nishimura Hideki, Kusama Ritsu, Kobayashi Minatsu, Ishihara Junko, Yamamoto Seiichiro, Hanaoka Tomoyuki, Tsugane Shoichiro

Abstract excerpt

We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese...

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PMID: 20432167
DOI: 10.1080/01635580903441279

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SHBG

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