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Article

Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancer.

Pharmacogenetics and genomics - 1 Feb 2007

Dai Qi, Xu Wang-Hong, Long Ji-Rong, Courtney Regina, Xiang Yong-Bing, Cai Qiuyin, Cheng Jiarong, Zheng Wei, Shu Xiao-Ou

Abstract excerpt

BACKGROUND: In-vitro studies have found that soy isoflavones can inhibit the activity of 17beta-hydroxysteroid dehydrogenase type I, a key enzyme in catalyzing estrone (E1), to the biologically more active estradiol (E2). OBJECTIVE: We hypothesized that soy food consumption may interact with polymorphisms in the 17beta-HSD1 gene in the development of endometrial cancer and evaluated this hypothesis in the...

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Source

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Identifiers

PMID: 17301695
DOI: 10.1097/FPC.0b013e32801112a1
PMCID: PMC2238679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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