Article
Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women.
Maturitas - 1 Dec 2015
Hosono Satoyo, Ito Hidemi, Oze Isao, Higaki Yasuki, Morita Emi, Takashima Naoyuki, Suzuki Sadao, Shimatani Keiichi, Mikami Haruo, Ohnaka Keizo, Ozaki Etsuko, Katsuura-Kamano Sakurako, Kubo Michiaki, Nagata Chisato, Naito Mariko, Hamajima Nobuyuki, Tanaka Hideo
Abstract excerpt
OBJECTIVE: Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. METHODS: We conducted a cross-sectional study. 785 Japanese natural postmenopausal...
Topics
- Aged
- Aromatase
- Body Mass Index
- Cross-Sectional Studies
- Estradiol
- Estradiol Dehydrogenases
- Estrone
- Female
- Humans
- Japan
- Middle Aged
- Overweight
- Polymorphism, Single Nucleotide