Article
Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.
Cancer science - 1 May 2009
Iwasaki Motoki, Hamada Gerson Shigeaki, Nishimoto Inês Nobuko, Netto Mario Mourão, Motola Juvenal, Laginha Fábio Martins, Kasuga Yoshio, Yokoyama Shiro, Onuma Hiroshi, Nishimura Hideki, Kusama Ritsu, Kobayashi Minatsu, Ishihara Junko, Yamamoto Seiichiro, Hanaoka Tomoyuki, Tsugane Shoichiro
Abstract excerpt
Epidemiologic studies have shown an inverse association between isoflavones and breast cancer risk. Because isoflavones bind estrogen receptors, we hypothesized that polymorphisms in the estrogen receptor genes might modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based case-control studies of patients aged 20-74 years with primary, incident, histologically confirmed...
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