Article
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Chinese medical journal - 20 Sept 2005
Han Ding-Fen, Zhou Xin, Hu Ming-Bai, Xie Wei, Mao Zong-fu, Chen Dong-e, Liu Fang, Zheng Fang
Abstract excerpt
BACKGROUND: Endogenous estrogen plays a very important role in the carcinogenesis and progression of breast cancer. The enzymes involved in the biosynthesis and metabolism of estrogen have been proposed to contribute to this effect. To examine this hypothesis, we conducted a case-control study to investigate the relationship between polymorphisms of genes responsible for estrogen biosynthesis (CYP17, cytochrome...
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