Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

doi:10.1007/s10549-008-9998-0

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Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

Breast cancer research and treatment - 1 Mar 2009

Zhang Lina, Gu Lin, Qian Biyun, Hao Xishan, Zhang Wei, Wei Qingyi, Chen Kexin

Abstract excerpt

Estrogen plays a role in breast cancer development, and genetic polymorphisms in estrogen receptor gene ER-alpha and genes regulating estrogen biosynthesis and metabolisms are associated with the risk of breast cancer in women in western countries. Therefore, we hypothesized that SNPs in ER-alpha and other estrogen-metabolizing genes contribute to breast cancer risk in Chinese women. In this study, we genotyped...

Topics

Adult
Aromatase
Asian People
Base Sequence
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Carcinoma, Medullary
Case-Control Studies
Estradiol
Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Estrogens

Female

Genotype

Humans

Middle Aged

Molecular Sequence Data

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 18629629
DOI: 10.1007/s10549-008-9998-0

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