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Article

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.

Circulation research - 11 Jun 2010

Guo Tao, Cornea Razvan L, Huke Sabine, Camors Emmanuel, Yang Yi, Picht Eckard, Fruen Bradley R, Bers Donald M

Abstract excerpt

RATIONALE: FK506-binding proteins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent protein kinase A (PKA)-dependent phosphorylation of RyR2 was proposed to interrupt FKBP12.6-RyR2 association and activate RyR2. However, the function of FKBP12.6/12 and role of PKA phosphorylation in cardiac myocytes are controversial. OBJECTIVE: To directly measure in situ binding of...

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Identifiers

PMID: 20431056
DOI: 10.1161/CIRCRESAHA.110.219816
PMCID: PMC2895429

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