Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes.

doi:10.1093/cvr/cvw247

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Article

Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes.

Cardiovascular research - 1 Mar 2017

Zhao Yan-Ting, Guo Yun-Bo, Gu Lei, Fan Xue-Xin, Yang Hua-Qian, Chen Zheng, Zhou Peng, Yuan Qi, Ji Guang-Ju, Wang Shi-Qiang

Abstract excerpt

Aims: The heart contraction is controlled by the Ca2+-induced Ca2+ release (CICR) between L-type Ca2+ channels and ryanodine receptors (RyRs). The FK506-binding protein FKBP12.6 binds to RyR subunits, but its role in stabilizing RyR function has been debated for long. Recent reports of high-resolution RyR structure show that the HD2 domain that binds to the SPRY2 domain of neighbouring subunit in FKBP-bound RyR1...

Topics

Animals
Arrhythmias, Cardiac
Calcium Channels, L-Type
Calcium Signaling
Genotype
Isoproterenol
Kinetics
Male
Membrane Potentials
Mice, Knockout
Microscopy, Confocal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Myocytes, Cardiac

Patch-Clamp Techniques

Phenotype

Protein Binding

Protein Interaction Domains and Motifs

Receptor Cross-Talk

Source

Open in PubMed Open full text

Identifiers

PMID: 28077437
DOI: 10.1093/cvr/cvw247
PMCID: PMC5852519

Genes

SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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