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Article

Altered function and regulation of cardiac ryanodine receptors in cardiac disease.

Trends in biochemical sciences - 1 Dec 2003

Wehrens Xander H T, Marks Andrew R

Abstract excerpt

In cardiac muscle, the ryanodine receptor (RyR2) on the sarcoplasmic reticulum (SR) releases the calcium required for muscle contraction. The magnitude of Ca(2+) release by RyR2, which is subject to regulation by several physiological mediators, determines cardiac contractility. In heart failure, chronic stimulation of the beta-adrenergic signaling pathway leads to hyperphosphorylation of RyR2 by protein kinase...

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Source

Identifiers

PMID: 14659699
DOI: 10.1016/j.tibs.2003.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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