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Article

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease.

The Biochemical journal - 15 Apr 2009

Zissimopoulos Spyros, Thomas N Lowri, Jamaluddin Wan W, Lai F Anthony

Abstract excerpt

In the present paper we show that distinct human RyR2 (ryanodine receptor type 2) inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 (12.6 kDa FK506-binding protein) binding compared with the wild-type. Oxidizing conditions result in decreased FKBP12.6 binding, but to the same extent as for the wild-type. Our findings suggest that FKBP12.6 regulation of RyR2 is...

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Identifiers

PMID: 19226252
DOI: 10.1042/BJ20082324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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