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Article

Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer.

The Journal of biological chemistry - 18 Jun 2010

Cornea Razvan L, Nitu Florentin R, Samsó Montserrat, Thomas David D, Fruen Bradley R

Abstract excerpt

The 12-kDa FK506-binding proteins (FKBP12 and FKBP12.6) are regulatory subunits of ryanodine receptor (RyR) Ca(2+) release channels. To investigate the structural basis of FKBP interactions with the RyR1 and RyR2 isoforms, we used site-directed fluorescent labeling of FKBP12.6, ligand binding measurements, and fluorescence resonance energy transfer (FRET). Single-cysteine substitutions were introduced at five...

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Identifiers

PMID: 20404344
DOI: 10.1074/jbc.M109.066944
PMCID: PMC2885200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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