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Article

Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2004

Tang Wei, Ingalls Christopher P, Durham William J, Snider Jessica, Reid Michael B, Wu Gangyi, Matzuk Martin M, Hamilton Susan L

Abstract excerpt

The immunophilin FKBP12 binds the skeletal muscle Ca2+ release channel or ryanodine receptor (RyR1), but the functional consequences of this interaction are not known. In this study, we have generated skeletal muscle specific FKBP12-deficient mice to investigate the role of FKBP12 in skeletal muscle. Primary myotubes from these mice show no obvious change in either Ca2+ stores or resting Ca2+ levels but display...

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Identifiers

PMID: 15289441
DOI: 10.1096/fj.04-1587fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency.PMID 15289441Read ↗

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RyR1-mediated Ca2+-induced Ca2+ release plays a negligible role in excitation-contraction coupling of normal skeletal muscle.Semantic proximity Read ↗

Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene.Semantic proximity Read ↗

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