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Article

Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor.

The Journal of biological chemistry - 28 May 1999

Xin H B, Rogers K, Qi Y, Kanematsu T, Fleischer S

Abstract excerpt

FK506-binding protein (FKBP12) has been found to be associated with the skeletal muscle ryanodine receptor (RyR1) (calcium release channel), whereas FKBP12.6, a novel isoform of FKBP, is selectively associated with the cardiac ryanodine receptor (RyR2). For both RyRs, the stoichiometry is 4 FKBP/RyR. Although FKBP12.6 differs from FKBP12 by only 18 of 108 amino acids, FKBP12.6 selectively binds to RyR2 and...

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Identifiers

PMID: 10336416
DOI: 10.1074/jbc.274.22.15315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor.PMID 10336416Read ↗

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