Article
Characterization of human embryonic stem cells with features of neoplastic progression.
Nature biotechnology - 1 Jan 2009
Werbowetski-Ogilvie Tamra E, Bossé Marc, Stewart Morag, Schnerch Angelique, Ramos-Mejia Veronica, Rouleau Anne, Wynder Tracy, Smith Mary-Jo, Dingwall Steve, Carter Tim, Williams Christopher, Harris Charles, Dolling Joanna, Wynder Christopher, Boreham Doug, Bhatia Mickie
Abstract excerpt
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers, they may be misconstrued as superior hES cells with enhanced 'stemness'. We characterize two variant hES cell lines...
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