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In vivo differentiated human embryonic stem cells can acquire chromosomal aberrations more frequently than in vitro during the same period.

Stem cells and development - 10 Dec 2012

Zucchelli Marco, Ström Susanne, Holm Frida, Malmgren Helena, Sahlén Sigrid, Religa Piotr, Hovatta Outi, Kere Juha, Inzunza José

Abstract excerpt

Human embryonic stem cells (hESCs) are regarded as a promising approach to generate transplantable cells for the treatment of several diseases. These cells offer an immense potential as a source of cells for regenerative medicine, but the possible ability of these cells to produce tumors in vivo presents a major impediment for the achievement of this potential in clinical reality. hESCs can obtain growth...

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Identifiers

PMID: 22709429
DOI: 10.1089/scd.2012.0066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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