Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical implications of c-Kit mutations in acute myelogenous leukemia.

Current hematologic malignancy reports - 1 Apr 2009

Malaise Muriel, Steinbach Daniel, Corbacioglu Selim

Abstract excerpt

c-Kit is a receptor tyrosine kinase (RTK) with a pivotal role in melanogenesis, gametogenesis, and hematopoiesis. Aberrantly activated RTK and related downstream signaling partners were identified as key elements in the molecular pathogenesis of several malignancies. This finding culminated in a two-class model integrating constitutive activating and maturation arrest-inducing mutations as key elements for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid

Share to Prognosis

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins c-kit

Share to Treatment Outcome

Source

Identifiers

PMID: 20425418
DOI: 10.1007/s11899-009-0011-8

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical implications of c-Kit mutations in acute myelogenous leukemia.PMID 20425418Read ↗

c-Kit Receptors as a Therapeutic Target in Cancer: Current InsightsSemantic proximity Read ↗

C-KIT signaling in cancer treatment.Semantic proximity Read ↗

Therapeutic targeting of c-KIT in cancer.Semantic proximity Read ↗

Receptor tyrosine kinase alterations in AML - biology and therapy.Semantic proximity Read ↗

Normal and oncogenic forms of the receptor tyrosine kinase kit.Semantic proximity Read ↗

A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitorsSemantic proximity Read ↗

Targeting c-Kit mutations: basic science to novel therapies.Semantic proximity Read ↗

Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.Semantic proximity Read ↗

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells.Semantic proximity Read ↗

Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST).Semantic proximity Read ↗

[The significance of C-KIT gene mutations in the diagnosis and prognosis of malignant tumors].Semantic proximity Read ↗

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.