[The significance of C-KIT gene mutations in the diagnosis and prognosis of malignant tumors].

Abstract excerpt

Mutations in the C-KIT gene encoding type III receptor tyrosine kinase that regulates cellular processes, such as differentiation, survival, proliferation, migration, and apoptosis, are found in some neoplasms: gastrointestinal stromal tumor, mastocytosis, melanoma, breast carcinomas, myeloid leukemias, and a number of others. Tumors that exhibit these mutations are sensitive to therapy with tyrosine kinase...

Topics

• Gastrointestinal Stromal Tumors
• Humans
• Melanoma
• Mutation
• Prognosis
• Proto-Oncogene Proteins c-kit