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Article

Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.

Expert opinion on therapeutic targets - 1 Jun 2004

Banerji Lolita, Sattler Martin

Abstract excerpt

Myeloid leukaemias are frequently associated with translocations and mutations of tyrosine kinase genes. The products of these oncogenes, including BCR-ABL, TEL-PDGFR, Flt3 and c-Kit, have elevated tyrosine kinase activity and transform haematopoietic cells, mainly by augmentation of proliferation and enhanced viability. Activated ABL kinases are associated with chronic myeloid leukaemia. Mutations in...

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Identifiers

PMID: 15161429
DOI: 10.1517/14728222.8.3.221

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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