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A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitors

1 Oct 2021

Abstract excerpt

Receptor tyrosine kinases play an important role in many cellular processes, and their dysregulation leads to diseases, most importantly cancer. One such receptor tyrosine kinase is c-Kit, a type-III receptor tyrosine kinase, which is involved in various intracellular signaling pathways. The role of different mutant isoforms of c-Kit has been established in several types of cancers. Accordingly, promising c-Kit...

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PMID: 34606974
DOI: 10.1016/j.bbcan.2021.188631

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