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Article

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia.

International journal of molecular sciences - 23 Apr 2022

Katagiri Seiichiro, Chi SungGi, Minami Yosuke, Fukushima Kentaro, Shibayama Hirohiko, Hosono Naoko, Yamauchi Takahiro, Morishita Takanobu, Kondo Takeshi, Yanada Masamitsu, Yamamoto Kazuhito, Kuroda Junya, Usuki Kensuke, Akahane Daigo, Gotoh Akihiko

Abstract excerpt

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35563085
DOI: 10.3390/ijms23094694
PMCID: PMC9103326

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