Article
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells.
Drug design, development and therapy - 1 Jan 2016
Abbaspour Babaei Maryam, Kamalidehghan Behnam, Saleem Mohammad, Huri Hasniza Zaman, Ahmadipour Fatemeh
Abstract excerpt
c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastrointestinal stromal...
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