Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST).

Gene - 15 Oct 2007

Ali Safdar, Ali Sher

Abstract excerpt

c-Kit encodes for the receptor tyrosine kinase (RTK) and belongs to type III receptor family. This includes platelet derived growth factor (PDGF) alpha and beta and macrophage colony stimulating factor (mCSF) apart from others. Their characteristic features are the presence of five immunologlobulin like domains in the extracellular region and 70-100 residues long kinase insert domain in the cytoplasmic region....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Piperazines
Share to Proto-Oncogene Proteins c-kit
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Imatinib Mesylate

Share to Pyrimidines

Share to Stem Cell Factor

Share to Stromal Cells

Source

Identifiers

PMID: 17659849
DOI: 10.1016/j.gene.2007.06.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST).PMID 17659849Read ↗

Receptor tyrosine kinase kit and gastrointestinal stromal tumours: an overview.Semantic proximity Read ↗

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical ImplicationsSemantic proximity Read ↗

C-KIT signaling in cancer treatment.Semantic proximity Read ↗

Molecular basis and management of gastrointestinal stromal tumors.Semantic proximity Read ↗

Biology of Gastrointestinal Stromal Tumors: <i>KIT</i> Mutations and BeyondSemantic proximity Read ↗

Gastrointestinal stromal tumors (GISTs): from science to targeted therapy.Semantic proximity Read ↗

c-Kit Receptors as a Therapeutic Target in Cancer: Current InsightsSemantic proximity Read ↗

The role of KIT in the management of patients with gastrointestinal stromal tumors.Semantic proximity Read ↗

Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options.Semantic proximity Read ↗

Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis.Semantic proximity Read ↗

Gastrointestinal stromal tumors: overview of pathologic features, molecular biology, and therapy with imatinib mesylate.Semantic proximity Read ↗

Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.