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Article

C-KIT signaling in cancer treatment.

Current pharmaceutical design - 1 Jan 2014

Stankov Karmen, Popovic Stevan, Mikov Momir

Abstract excerpt

Tumor progression is strongly associated with the activity of receptor tyrosine kinases (RTKs) and their intracellular signal transduction pathways, which regulate several cell functions including proliferation, apoptosis, motility, adhesion and angiogenesis. Detailed structural and functional studies of RTKs, including the stem cell factor receptor c-KIT, revealed the complexity of these receptor systems and...

Topics

Cell Proliferation
Humans
Models, Biological
Molecular Targeted Therapy
Mutation
Neoplasms
Protein Kinase Inhibitors
Proto-Oncogene Proteins c-kit
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23944364
DOI: 10.2174/13816128113199990593

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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