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Article

Roles of LRRK2 and its orthologs in protecting against neurodegeneration and neurodevelopmental defects

30 Apr 2025

Abstract excerpt

gene are the most prevalent risk factors for Parkinson's disease (PD). Whereas studies in model organisms have long indicated that the orthologs of the wild-type LRRK proteins protect against neurodegeneration, newer findings indicate that they also protect against neurodevelopmental defects. This normal role of the LRRK proteins can be disrupted by either gain-of-function (GOF) or loss-of-function (LOF)...

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PMID: 40371391
DOI: 10.3389/fcell.2025.1569733

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