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LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives.

Advances in neurobiology - 1 Jan 2017

Rideout Hardy J, Re Diane B

Abstract excerpt

Since its cloning and identification in 2004, considerable gains have been made in the understanding of the basic functionality of leucine-rich repeat kinase 2 (LRRK2), including its kinase and GTPase activities, its protein interactors and subcellular localization, and its expression in the CNS and peripheral tissues. However, the mechanism(s) by which expression of mutant forms of LRRK2 lead to the death of...

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PMID: 28353285
DOI: 10.1007/978-3-319-49969-7_10

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