Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae.

PLoS genetics - 1 Jul 2016

Claussin Clémence, Chang Michael

Abstract excerpt

Most human somatic cells express insufficient levels of telomerase, which can result in telomere shortening and eventually senescence, both of which are hallmarks of ageing. Homology-directed repair (HDR) is important for maintaining proper telomere function in yeast and mammals. In Saccharomyces cerevisiae, Rad52 is required for almost all HDR mechanisms, and telomerase-null cells senesce faster in the absence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatids
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Lysine

Share to Rad52 DNA Repair and Recombination Protein

Share to Sister Chromatid Exchange

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 27428329
DOI: 10.1371/journal.pgen.1006176
PMCID: PMC4948829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae.PMID 27428329Read ↗

Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.Semantic proximity Read ↗

Reappearance from Obscurity: Mammalian Rad52 in Homologous RecombinationSemantic proximity Read ↗

An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.Semantic proximity Read ↗

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Semantic proximity Read ↗

Replication stress as a source of telomere recombination during replicative senescence inSaccharomyces cerevisiaeSemantic proximity Read ↗

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Semantic proximity Read ↗

Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.Semantic proximity Read ↗

Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere ShorteningSemantic proximity Read ↗

A two-step model for senescence triggered by a single critically short telomere.Semantic proximity Read ↗

The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.