Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing.

Chromosoma - 1 Aug 2008

Bhattacharyya M K, Matthews K M, Lustig A J

Abstract excerpt

Mre11 is a central factor in creating an optimal substrate for telomerase loading and elongation. We have used a G2/M synchronized telomere-healing assay as a tool to separate different functions of Mre11 that are not apparent in null alleles. An analysis of healing efficiencies of several mre11 alleles revealed that both nuclease and C-terminal mutations led to a loss of healing. Interestingly,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to Endodeoxyribonucleases
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plasmids

Share to Saccharomyces cerevisiae Proteins

Share to Telomere

Share to Two-Hybrid System Techniques

Share to Yeasts

Source

Identifiers

PMID: 18335232
DOI: 10.1007/s00412-008-0153-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing.PMID 18335232Read ↗

An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.Semantic proximity Read ↗

Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.Semantic proximity Read ↗

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.Semantic proximity Read ↗

Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.Semantic proximity Read ↗

Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance.Semantic proximity Read ↗

A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis.Semantic proximity Read ↗

MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.Semantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres.Semantic proximity Read ↗

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.Semantic proximity Read ↗

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.